We are pleased to announce that the painless solution used in Pria Clinic's Pain Zero Rejuran has been granted a patent by the Korean Intellectual Property Office (KIPO) following an extensive examination process.
📜 Patent Registration Details
- Patent No.: 10-3029637
- Title of Invention: PHARMACEUTICAL COMPOSITION FOR INJECTION AND METHOD FOR USING THEREOF (주사용 약제 및 그 사용방법)
- Registration Date: October 1, 2026
In recent years, the number of clinics offering painless Rejuran has grown considerably. Yet the name alone tells you very little about what actually sets one apart from another. In most cases, there is no verification of what is mixed into the Rejuran or the standards by which it is prepared.
At Pria Clinic, where authenticity is our most important value, we chose to answer this with a patent.
Why Does Rejuran Hurt?
Polynucleotide (PN), the key active ingredient in Rejuran, consists of DNA fragments derived from salmon or trout and is effective in promoting skin regeneration. However, because it is acidic and highly viscous, it causes a stinging, aching sensation as it is injected into the skin.
We explained the mechanism behind this pain, and how Pria Clinic's Pain Zero Rejuran was first developed, in a previous article.
👉 Painless Rejuran: Skin Regeneration Without the Pain
Three Patented Core Technologies
The official title of the patent is "PHARMACEUTICAL COMPOSITION FOR INJECTION AND METHOD FOR USING THEREOF." It covers the composition, manufacturing method, and method of use of a painless solution that reduces the pain caused by injecting skin boosters such as Rejuran.
① Physicochemical properties close to those of body fluids
The solution brings acidic Rejuran to a pH similar to that of body fluids, reducing irritation during injection, while its viscosity is adjusted to maximize hydration effect.
② A consistent manufacturing process
The painless solution is produced under controlled temperature and pressure conditions, so you receive Painless Rejuran of the same quality every time.
③ A formulation validated through research
Pria Clinic compared the painless solution across multiple formulation conditions and patented the one that delivered the greatest pain relief while preserving Rejuran's skin-elasticity benefits.
The resulting painless solution is mixed with Rejuran Healer at a 1:2 ratio to prepare Painless Rejuran.
The Trust a Patent Provides
With so many clinics offering similar treatments, choosing a clinic and a treatment can be difficult. Pria Clinic would like to offer the following criteria to guide your choice.
1. A technology examined by the patent office
A patent is not granted simply because one applies for it. To be registered, a technology must be recognized through KIPO's examination as new (novelty) and not readily conceivable (inventive step) compared with existing technologies. Pria Clinic's painless solution passed this examination and was registered as Patent No. 10-3029637.
2. Anyone can verify it
Registered patents are published on KIPRIS, KIPO's patent information search service. By searching the patent number, anyone can confirm the registration and review the contents of the patent.
3. The same quality, every time
Because the ingredient ratios and preparation conditions are precisely specified in the patent, we prepare and administer every treatment in strict accordance with them. Combined with the use of 34G microneedles, this is the standard that ensures results do not vary depending on the physician or the day of your visit.
4. Patented Painless Rejuran is available only at Pria Clinic
A registered patent is officially recognized by the state and protected by law. Many clinics offer painless Rejuran, but Pria Clinic is the only clinic that prepares and administers Rejuran using a patented painless solution.
5. No sedation required
Sedation requires fasting and recovery time after the procedure, and carries medication-related risks. The greatest advantage of Pria Clinic's Painless Rejuran is that the solution itself is designed to reduce pain, so you can even have the treatment during a lunch break and return straight to your day.
How the Treatment Works
1. Consultation and skin assessment: We evaluate your skin condition and the areas to be treated. 2. Prepared on the day, in front of you: 1cc of the patented painless solution is combined with 2cc of Rejuran Healer to prepare Painless Rejuran. We show you this process directly. 3. Treatment with 34G microneedles: Finer than standard needles, 34G microneedles minimize pain stimulation. Because microneedles are also shorter than standard needles, they allow precise delivery into the dermis at a depth of 2mm, the layer targeted by skin booster treatments. 4. Aftercare: The small bumps that form at injection points typically subside within 1–2 days.
Frequently Asked Questions
Q. How can I verify that the patent has been granted?
A. You can check the registration details by searching on KIPRIS (www.kipris.or.kr).
Q. Is it completely painless?
A. Pain perception varies from person to person. The painless solution is designed not to "eliminate" pain but to significantly reduce it, and most patients find it far more comfortable than standard Rejuran.
Q. Is Painless Rejuran also available for the eye area (Rejuran i)?
A. Yes. Painless Rejuran for the eye area is prepared by adding the same painless solution to Rejuran i.
In Closing
Painless Rejuran has become a widely known treatment offered by many clinics. However, only one clinic offers Painless Rejuran officially recognized through a patent.
Experience authentic Painless Rejuran at Pria Clinic.
> Patent No. 10-3029637 | PHARMACEUTICAL COMPOSITION FOR INJECTION AND METHOD FOR USING THEREOF > Pria Clinic Painless Rejuran
Medical Information Notice — This column provides general medical information and does not recommend specific treatments. The appropriate treatment may vary depending on individual skin conditions and health status.
